Travelling exhibitions require important decisions regarding collections and design. All of the aspects easily managed in the home museum are difficult to control when an exhibition travels. Decisions on the selection of collections require close collaboration between curators and designers to find optimal solutions for preserving the exhibition’s core scientific content. Choices regarding museographical elements can also deeply impact the final design. Should authentic artifacts and specimens always be included in the design? If so, what are the constraints on the exhibition site and design? What types of collections or artifacts may be replaced by replicas? What types of displays can be replaced by text panels? How does the display of specimens vs replicas affect exhibition design?